The use of hydroxychloroquine in patients with a history of gastrointestinal motility disorders requires caution due to potential effects on gastrointestinal smooth muscle function. hydroxychlor tab 200mg Hydroxychloroquine has been associated with gastrointestinal adverse reactions, including dyspepsia and constipation, in some cases. Healthcare providers should monitor gastrointestinal symptoms regularly in patients receiving hydroxychloroquine therapy and provide supportive care as needed.