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Carhart-Harris RL, Erritzoe D, Williams T, Stone JM, Reed LJ, Colasanti A, Tyacke RJ, Leech R, Malizia AL, Murphy K, Hobden P, Evans J, Feilding A, Wise RG, Nutt DJ. Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin. Proc Natl Acad Sci U S A. 2012;109(6):2138-43. doi: 10.1073/pnas.1119598109 What’s more, mental health professionals supported both treatment groups during and after the trial. The success of psilocybin is heavily dependent on the environment in which it is taken. This means it is a bad idea to use it for self-medicating. Also, patients were carefully selected for psilocybin-assisted therapy based on their history to avoid the risk of psychosis and other adverse effects. More recently, psilocybin has gained attention as a new paradigm in the treatment of depression. Psilocybin, a classic hallucinogen, effects glutamate levels in key areas of the brain, including the medial prefrontal cortex and hippocampus that are associated with positive changes in self-experience and increased feelings of unity with others and one’s surroundings (Nour and Carhart-Harris, 2017; Mason et al., 2020). Distortions of self-experience may be an important mechanism to target in the treatment of depression (Carhart-Harris and Goodwin, 2017).

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While initial research surrounding microdosing does seem promising, there isn’t enough conclusive evidence to make blanket statements about the effectiveness. In November 2020, the state of Oregon passed Measure 109 to legalize psilocybin for people age 21 and older. In another vote, psilocybin was decriminalized. Proponents of psilocybin legalization in Oregon promote its use for medical conditions, such as depression, anxiety, or PTSD. The new law will make psilocybin more accessible to people who need them clinically. Measure 109 will be enacted after a developmental stage is completed, expected to be a two year process. Make an Appointment Researchers found that the participants’ depression levels remained low 1-, 3-, 6- and 12-months after the treatment. While this is dope news, researchers noted that more research is needed to explore the link between psilocybin and depression. Specifically, we still need to know if treatments can last longer than 12 months.

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